The Australian pair will play subject to a negative COVID test and will then be available for the rest of the tournament.
Head returns to captain the side as the club’s third-highest runscorer with 1279 from 44 innings, at a strike rate of 136.64.
The Strikers are also boosted by the return of Neser, who is second on the club’s most capped list with 58 games.
Peter Siddle is hopeful of a return to the field after a big week on the training track, since fracturing his thumb against the Melbourne Renegades almost two weeks ago.
Play begins at 6:45pm (ACDT) on Thursday at Adelaide Oval, and the playing XI and X-Factor Substitutes will be announced at the pre-game bat flip.
Tickets are available via Ticketek and must be pre-purchased prior to arrival.
Adelaide Strikers’ 19-player squad
Travis Head (c)
In: Head, Neser