Siddle injured his left thumb in what was a nasty blow off a Jake Fraser-McGurk straight drive in the match against the Melbourne Renegades on Friday night.
The 36-year-old remained on the field and bowled the final over, yet the best course of action is for him to miss Monday’s game.
With a five-day break before the return Stars fixture at the MCG, it is hopeful that Siddle will again be available for selection.
Travis Head and Michael Neser remain with the Australian Men's Cricket Team in Sydney.
Play begins at 6:45pm (ACDT) on Monday, and the final XI and X-Factor substitutes will be announced at the pre-game bat-flip.
The match is Rashid Khan’s last match of KFC BBL|10 as he soon departs for Afghanistan’s ODI series against Ireland.
Tickets are available via Ticketek and must be pre-purchased prior to arrival. Patrons are advised to please monitor the SA Health website. DO NOT attend if you are unwell or have visited a location listed on the contact tracing page. Patrons are advised to follow SA Health instructions.
Adelaide Strikers’ 17-player squad
Alex Carey (c)
Out: Peter Siddle