Neser's whirlwind 122 off just 81 deliveries earned him the player of the match award, guiding Queensland to 9-292 off their 41 overs chasing 304 to win in a rain-affected match.
Western Australia's total of 3-301 from 41 overs was slightly adjusted to a target of 304 for a Queensland victory, with the Warriors winning by 11 runs on the DLS Method.
Neser and Bulls skipper Usman Khawaja (81 off 78) led the Bulls' revival after they had been 5-63, with Matthew Kelly the pick of the Warriors' bowlers, collecting 4-25 off eight overs.
Neser had taken the game to the final over with his seven sixes for the match, before being cruelly run-out with four balls to play.
The hard-hitting bowler will be in action when the Adelaide Strikers take on the Sydney Thunder in their season opener on December 22 at Adelaide Oval, general tickets are on sale from Monday, 16 October.