Set 174 to win, the winless Renegades slumped to 2/10 early and never recovered, dismissed for 110 in 17.4 overs against a disciplined and economical Strikers attack spearheaded by seamer Peter Siddle (3/14) and spin pair Rashid Khan (2/19) and the returning Travis Head (2/26).
Strikers captain Head played an unlikely lead role with the ball by castling openers Marcus Harris (four) and Shaun Marsh (21).
Siddle sent the middle stump of Sam Harper (five) cartwheeling before sprinting from third man to backward point to pouch a marvellous, diving catch to snare Mohammad Nabi (six). He then sent Samit Patel and Daniel Christian packing.
Beau Webster was trapped leg-before to Rashid for a gutsy 49, but his innings wasn’t enough to stop the reigning champions from recording their ninth loss from as many starts.
Rashid claimed compatriot Nabi during the win to become the third player to take 50 BBL wickets for the club and the fastest player in Big Bash history to reach the milestone in innings bowled.
Earlier, Jon Wells (58) and Matt Short (41) lifted the Strikers out of a spot of bother and to a competitive 6/173.
Jake Weatherald (27), Head (22) and Phil Salt (18) all holed out trying to go big as the home side teetered at 4/81 before the recovery came.
At one stage, Wells - who has 292 runs at 73 for the tournament - and Short went 43 deliveries without a boundary while in wicket-preservation mode, before finishing with a flourish, 76 coming from the final six overs to leave the Renegades reeling.
The Strikers head to the Gabba to confront the Brisbane Heat on Tuesday afternoon in their next match of the tournament.