Hurricanes opener Matthew Wade powered his side to victory with 84 from 49 deliveries alongside D'Arcy Short with 73 from 52 to reach the target total of 155 with 19 balls to spare.
Strikers stand-in skipper Colin Ingram led a late fightback for the home side in the opening innings with an unbeaten 67 off 36 balls which included three towering sixes and another six boundaries.
The returning Alex Carey and busy batsman Jon Wells contributed 28 each but the Strikers struggled to gain any significant momentum throughout their innings.
Hobart's Jofra Archer took 2/22, James Faulkner claimed 2/24 and James Meredith finished with 1/39 to pile the pressure on the home side’s batting order.
The result marks the reigning champions’ fifth loss from nine games while Hobart extended its advantage at the top of the BBL|08 standings with eight victories and just one loss this summer.
The Hurricanes now hold a six-point gap ahead of the second-placed Sydney Sixers.
The Strikers travel to Moe in country Victoria to take on the Melbourne Stars in their next clash on Wednesday afternoon.