The defending champions secured their second straight victory and handed the Renegades their third defeat in a row in the Strikers’ maiden Big Bash match at the venue.
Openers Jake Weatherald and Alex Carey set the tone for the Strikers with an explosive 60-run partnership to lay the foundations for the visitors.
Carey's dismissal led to a mini-collapse on a challenging pitch as big-hitters Colin Ingram (6) and Jake Lehmann (2) fell cheaply.
But Weatherald remained on the attack throughout, blasting his biggest score of BBL|08 so far with an eye-catching 71 off only 44 deliveries which included three sixes and six fours.
His innings was only brought to an end by a tight run-out call. Teammate Matt Short was also unluckily caught short in similar fashion for just 1.
Some late big hitting from Rashid Khan (21* off 7) and a handy contribution from Jon Wells (22* off 22) helped the Strikers to 6/158.
Adelaide’s brilliant bowling unit then went to work to grind the Renegades into submission.
Beau Webster's 33 helped close the margin late but the Renegades had little hope after losing both Mackenzie Harvey and Sam Harper (both 1) during a powerplay which yielded just 21 runs.
Skipper Tom Cooper (16) and veteran Cameron White (17) soon followed, the latter trapped LBW after failing to pick a well-disguised Rashid wrong'un.
The Afghan star (1/18) proved a deadly combination with fellow leg-spinner Liam O'Connor, who snared 2/21 after being recalled for his first game of the season.
The hosts limped to 9/126 from their 20 overs and never seriously looked like challenging Adelaide’s total.
The Strikers currently sit in second position on the BBL table after five matches and will host the Sydney Sixers at Adelaide Oval on Sunday.
In-form seamer Peter Siddle is expected to return to the Strikers’ lineup after being released from duties with the Australian Test squad. Tickets to the clash are available now.