The defending champions slumped to a fourth-straight loss against an in-form Sixers outfit which cruised past the Strikers’ total of 124 with almost six overs to spare on Tuesday night.
Jake Lehmann bettered his highest Big Bash score for the second match in a row with a fighting 46 but again had little support around him.
Opener Alex Carey was run out for the fourth time this summer for just 4 while fellow left-hander Weatherald skied a Dwarshuis delivery for 7 to put the visitors on the back foot from the outset.
Jon Wells (23 off 20 balls) and some late hitting from Michael Neser (31 off 21) helped lift the visitors’ run rate despite quality bowling from the home side.
Player of the Match Dwarshuis finished with club-record figures of 3/7 while Sean Abbott continued his strong BBL|08 to take 2/25.
The Strikers had to strike early with the ball and they did just that - allrounder Neser trapped the explosive Josh Philippe for 4 in the second over before Billy Stanlake breathed life into the contest by claiming James Vince for 9 to end the third.
But Sixers skipper Moises Henriques (61*) and opener Daniel Hughes (51*) put the hosts back on track in a match-winning 106-run partnership to inflict the Strikers’ first Big Bash loss at the venue.
It leaves the Strikers teetering in sixth spot on the tournament table with a 4-7 record after 11 matches. Adelaide must win its three remaining games and rely on other results to have any hope of a last-gasp finals appearance.
The Strikers travel to Launceston to take on the top-of-the-table Hobart Hurricanes on Thursday night in the club’s next BBL clash.